What is TAZZLE 20mg?
Tazzle 20mg is an FDA-approved prescription-only medication with tadalafil as its active
ingredient. It belongs to a class of drugs known as phosphodiesterase type 5 (PDE5) inhibitors
used as a short-term solution to Erectile Dysfunction (ED). Tadalafil relaxes the blood vessels
and enhances blood flow in the penile tissues when sexually aroused, leading to an erection.
Sexual arousal is necessary for tadalafil to work. Another use of Tazzle 20mg is to aid and
relieve the symptoms of Benign Prostatic Hyperplasia (BPH). In BPH, tadalafil relaxes the smooth
muscles in the prostate and bladder to relieve urinary symptoms, such as difficulty in starting
urination, weak stream, and the urge to urinate frequently.
Tazzle 20mg Stepwise Action mechanism
Sexual stimulation is a must
Tazzle does not cause spontaneous erections. It works only in response to sexual stimulation, as
the release of nitric oxide (NO) from nerve endings in the penis produces cGMP.
PDE5 Inhibition
Tadalafil, the active ingredient in Tazzle 20mg, is a PDE5 inhibitor. PDE5 (phosphodiesterase
type 5) is an enzyme found in the walls of blood vessels. This enzyme breaks down cyclic
guanosine monophosphate (cGMP), a chemical molecule that promotes the relaxation of smooth
muscle tissues. By inhibiting PDE5, tadalafil increases cGMP levels, allowing blood vessels in
the penis to relax.
Enhanced Blood Flow
Relaxed blood vessels in the penis allow increased blood flow during sexual stimulation. This
helps men achieve and sustain an erection sufficient for sexual activity.
What are the Uses and Benefits of TAZZLE 20mg?
Tazzle 20mg Uses
Erectile Dysfunction (ED)
Tazzle 20mg helps men achieve and sustain an erection during sexual activity. It works only with
sexual stimulation.
Benign Prostatic Hyperplasia (BPH)
Tazzle medication relieves urinary symptoms like difficulty urinating, weak stream, and frequent
urination. It works by relaxing the muscles in the bladder and prostate.
Combined ED and BPH Treatment
Suitable for men suffering from both erectile dysfunction and urinary symptoms of BPH.
Pulmonary Arterial Hypertension (PAH) (Off-label in some countries)
Reduces high blood pressure in the lungs by relaxing blood vessels, improving exercise ability.
Tazzle 20mg Benefits
Ease of Use
A single Tazzle pill provides long-lasting effects, reducing the need for multiple doses.
Dual Benefits
For men with ED and BPH, Tazzle 20mg addresses both conditions simultaneously.
Proven Efficacy
Backed by clinical studies and approved by regulatory authorities.
Long-Lasting Effectiveness
Duration: Effective for up to 36 hours, The Weekend Pill allows
for more spontaneous sexual activity without strict timing.
Rapid Onset
Tazzle kicks in within 30–60 minutes after consumption.
Improved Quality of Life
Tazzle enhances confidence and satisfaction in intimate relationships. It provides relief from
urinary symptoms associated with BPH, improving daily comfort.
Convenient Dosing
You can take Tazzle as needed, offering flexibility and spontaneity. It is available in lower
daily doses (2.5 mg or 5 mg) for men who prefer regular dosing to avoid planning.
Less Food Interference
You can take Tazzle with or without food. It maintains its efficacy even when consumed with a
heavy meal.
Safe and Well-Tolerated
The well-tolerated Tazzle has side effects that are usually mild and temporary.
What are the Safe Dosages of TAZZLE 20mg?
Start Low: First-time users or individuals with pre-existing conditions should
start with a lower dose (e.g., 5 mg or 10 mg) and adjust under medical supervision.
Maximum Daily Dose: Do not exceed 20 mg within 24 hours for ED.
Avoid Split Doses: Always take the prescribed amount in one dose as directed.
For Erectile Dysfunction (ED)
As Needed
Usual Dose: 10 mg, taken at least 30 minutes
before sexual activity.
Maximum Dose: 20 mg, based on individual tolerability and
efficacy.
Frequency: Not more than once per day.
Daily Dosing
Dose: 2.5 mg to 5 mg daily, same time.
Use: Ideal for men who engage in sexual activity multiple times per week and
prefer not to plan.
For Benign Prostatic Hyperplasia (BPH)
Dose: 5 mg daily.
Time of Day: Taken at the same time each day, with or without food.
For Combined ED and BPH
Dose: 5 mg daily.
Benefit: Provides continuous relief from both conditions.
Pulmonary Arterial Hypertension (PAH)
Usual Dose 20 mg, taken twice daily or as prescribed.
For Older Adults (65+)
Start with a lower dose to minimize side effects.
Liver or Kidney Impairment
Mild to Moderate Issues: You may need dosage adjustments, maybe a lower dose of
5 mg.
Severe Issues: Avoid using Tazzle 20mg as contraindicated or closely monitored
by a healthcare provider.
Avoid using alongside Nitrates: Taking tadalafil with nitrates (nitroglycerin,
isosorbide mononitrate, and dinitrate) can cause a dangerous drop in blood pressure.
Alcohol: Limit intake to reduce the risk of side effects like dizziness or low
blood pressure.
Grapefruit Juice: It can interfere with Tazzle 20mg metabolism, increasing drug
levels in the bloodstream and the risk of side effects.
Contraindicated in Certain Conditions: Avoid use in severe heart or liver
disease, recent stroke, or history of vision loss because of NAION.
How to take TAZZLE 20mg?
Swallow the tablet whole with a glass of water. Do not crush, chew, or split the tablet. Take one
tablet approximately 30 minutes to 1 hour before planned sexual activity. You can take Tazzle
20mg with or without meals. However, avoid consuming a high-fat meal before taking it, as this
may delay its onset of action.
The effects of Tazzle medication may last up to 36 hours, so there is no need to rush the timing.
Do not take more than one dose in 24 hours. Take one tablet at the same time every day,
regardless of sexual activity. Tazzle 2.5 mg or 5 mg are usually lower doses and allow for
spontaneous intimacy.
When Should I Avoid TAZZLE 20mg?
When Taking Nitrates
Examples are nitroglycerin, isosorbide dinitrate, or isosorbide mononitrate (used for chest pain
or heart problems). Combining tadalafil with nitrates can cause a severe drop in blood pressure,
which could be life-threatening.
If Advised Against Sexual Activity
Men with heart conditions (e.g., unstable angina or severe heart failure) may be at risk of
complications during sexual activity.
Severe Heart Problems
Avoid Tazzle medication if you have a heart attack within the last 90 days, severe arrhythmias
(irregular heartbeats), aortic stenosis, other severe cardiovascular disorders, or low blood
pressure.
Severe Liver or Kidney Disease
If you have severe hepatic (liver) impairment, the liver may not metabolize Tazzle 20mg properly,
leading to increased side effects.
Severe renal (kidney) impairment can prevent proper excretion of the drug, leading to
accumulation and toxicity.
Recent Stroke or Neurological Issues
If you have had a stroke in the last 6 months, avoid using Tazzle 20mg because of the risk of
cardiovascular complications.
Conditions like multiple sclerosis or uncontrolled epilepsy may require caution.
Allergic Reaction to Tadalafil or Ingredients
Avoid Tazzle if you are allergic to tadalafil or active ingredients. It may cause rash, swelling,
or difficulty breathing.
Eye Disorders
Examples of degenerative eye diseases are:
- Non-arteritic anterior ischemic optic neuropathy (NAION) causes sudden vision loss.
- Retinitis pigmentosa (a genetic eye condition).
Tazzle 20mg may increase the risk of vision loss in people with certain eye disorders.
Blood Pressure Issues
Avoid Tazzle if your blood pressure is significantly low (below 90/50 mm Hg).
If you have uncontrolled hypertension, consult your doctor before use.
Deformity of the Penis or Priapism Risk
Conditions like Peyronie’s disease, sickle cell anemia, leukemia, or multiple myeloma
increase the risk of priapism (prolonged and painful erections), which may require emergency
medical attention.
Use with Other ED Medications
Combining Tazzle with other PDE5 inhibitors (e.g., sildenafil, vardenafil) can lead to dangerous
side effects and overdose.
Pregnancy and Breastfeeding (For PAH Treatment)
Tazzle is not for women. However, for pulmonary arterial hypertension (PAH) treatment in women,
avoid using Tazzle 20mg during pregnancy or breastfeeding unless doctors deem it necessary by a
doctor.
Alcohol or Recreational Drug Use
Avoid excessive alcohol or drugs like poppers (amyl nitrite) while taking Tazzle, as these can
interact dangerously with the medication.
Avoid:
- Over 65 years of age and have not used tadalafil before.
- Taking other medications (e.g., alpha-blockers for blood pressure).
- Have a history of bleeding disorders or active stomach ulcers.
What are the Side effects of TAZZLE 20mg?
Common side effects of Tazzle are mild and subside as you get accustomed to the doses. Seek medical attention immediately if you notice the severe side effects and stop the doses.
Common TAZZLE 20mg Side Effects
- Headache
- Flushing (warmth or redness in the face, neck, or chest)
- Nasal Congestion or stuffy nose
- Indigestion (dyspepsia)
- Back Pain
- Muscle Aches (myalgia)
- Dizziness
- Leg Pain
- Nausea
- Blurred Vision
- Changes in Color Vision (difficulty distinguishing blue and green shades)
- Eye Irritation or Redness
- Ringing in the Ears (tinnitus)
Severe TAZZLE 20mg side effects
- Priapism (a prolonged, painful erection lasting over four hours):
- Severe Drop in Blood Pressure:
- Symptoms include fainting, severe dizziness, or light-headedness.
- Sudden Vision Loss:
- Sudden Hearing Loss: Accompanied by ringing in the ears or dizziness.
- Severe Allergic Reaction: rash, itching, swelling (especially of the face, tongue, or throat), severe dizziness, or difficulty breathing.
- Arrhythmia (irregular heartbeat)
- Heart problems
I was using Cialis for quite a few years but is very expensive. I am using Tazzle 20mg because I am 72 and my partner is 65, so I needed a higher dose which is safe. It does not give much side effects and the cost is much lower than Cialis.