Abel 40mg reduces the risk of stroke, heart attack, and Kidney Damage and prevents the stiffening of arteries, lowering the risk of heart disease. It improves kidney function by reducing pressure on blood vessels in the kidneys. It reduces the risk of heart failure by lowering fluid overload in the body. Abel 40mg maintains Electrolyte Balance Better than Other Diuretics. Chlorthalidone is a long-acting diuretic, but it has a lower risk of potassium depletion than other diuretics. It helps in reducing swelling (edema) without causing severe dehydration. Its once-daily convenience and Long-Lasting Effect provides 24-hour blood pressure control with just one pill. Clinically tested, proven, and FDA-approved, Abel 40mg ensures better patient compliance because of its once-daily dosing.
What is Abel 40mg?
Abel 40mg is a combination of two powerful antihypertensive agents:
- Azilsartan (40mg)–Angiotensin II Receptor Blocker (ARB)
- Chlorthalidone (12.5mg)–Thiazide-like Diuretic
The dual ingredients provide dual-action blood pressure control. They relax blood vessels and reduce fluid retention.
Scientific Mechanism of Action
Azilsartan (40mg)–Angiotensin II Receptor Blocker (ARB)
Blocks Angiotensin II Receptors (AT1 Receptors)
Angiotensin II is a hormone that narrows blood vessels and increases blood pressure. Azilsartan blocks AT1 receptors, preventing Angiotensin II from tightening blood vessels. It leads to vasodilation (widening/dilating of blood vessels), reducing blood pressure.
Reduces Aldosterone Secretion
Aldosterone causes sodium and water retention, increasing blood pressure. By reducing aldosterone, Azilsartan helps the body eliminate excess sodium and fluid.
Stronger and Longer-Lasting than Other ARBs
Azilsartan is more potent than Telmisartan, Olmesartan, and Losartan. It provides better 24-hour blood pressure control with a single dose.
Chlorthalidone (12.5mg)–Thiazide-Like Diuretic
Inhibits Sodium Reabsorption in Kidneys (Na+/Cl- Co-Transporter Blockade)
Abel works in the distal convoluted tubule of the kidney, blocking the Na+/Cl- co-transporter. It prevents sodium and water from being reabsorbed into the bloodstream. It leads to increased urine output (diuresis), reducing blood volume and lowering BP.
Enhances Effects of Azilsartan
By reducing blood volume, Chlorthalidone boosts the effectiveness of Azilsartan. This combination prevents fluid buildup beneficial for heart failure and kidney protection.
Longer-Lasting than Hydrochlorothiazide (HCTZ)
Chlorthalidone has a longer half-life than HCTZ, providing a more stable BP-lowering effect. It is 1.5 to 2 times more potent than HCTZ in reducing BP.
Overall Effects of Abel 40mg on the body
Blood Vessel Relaxation (Vasodilation)
Azilsartan widens blood vessels, reducing resistance and lowering BP.
Reduced Fluid Retention
Chlorthalidone removes excess sodium & water, decreasing blood volume and BP.
Improved Kidney Function
Lower blood pressure reduces kidney damage caused by hypertension.
Heart Protection
Reduces strain on the heart, lowering the risk of heart attacks, strokes, and heart failure.
Better 24-Hour BP Control
The combination ensures steady blood pressure throughout the day.
What are the Uses and Benefits of Abel 40mg?
Uses of Abel 40mg
High Blood Pressure (Hypertension)–Primary Use
Abel 40mg lowers high blood pressure by relaxing blood vessels (Azilsartan) and removing excess fluid (Chlorthalidone). It reduces the workload on the heart, preventing complications like heart attack and stroke.
Prevention of Heart Diseases
Abel helps protect against heart failure, heart attacks, and irregular heartbeats (arrhythmia). It prevents thickening of the heart muscles (left ventricular hypertrophy) caused by high BP.
Kidney Protection in Hypertensive Patients
Abel reduces kidney damage caused by high BP, especially in diabetic & chronic kidney disease (CKD) patients. Chlorthalidone helps remove excess sodium, reducing strain on the kidneys.
Reduces Stroke Risk
Lowering blood pressure reduces the risk of stroke, especially in older patients.
Fluid Retention & Swelling (Edema) Treatment–Secondary Use
Abel helps remove excess fluid buildup (edema) in patients with heart disease, liver disease, or kidney problems.
Benefits of Abel 40mg
Stronger & More Effective Than Other Hypertension Medications
- Azilsartan is the most potent ARB, better than Telmisartan, Losartan, and Olmesartan.
- Chlorthalidone is more effective than Hydrochlorothiazide (HCTZ) for BP control.
- It provides better 24-hour BP reduction with just one daily dose.
Dual-Action for Maximum Blood Pressure Control
- Azilsartan relaxes blood vessels and reduces BP.
- Chlorthalidone removes excess fluid, further lowering BP.
- It works faster and longer than other BP medications.
Reduces Risk of Heart Attack & Stroke
- It prevents artery stiffening, which reduces heart disease risk.
- It protects the brain from stroke-related damage caused by high BP.
Protects Kidneys & Improves Kidney Function
- It reduces kidney damage caused by hypertension, especially in diabetic patients.
- Removes excess sodium & fluid, helping kidneys function better.
Once-Daily Convenience & Better Compliance
- The long-acting formula ensures stable BP throughout the day.
- A single tablet per day makes it easier to follow treatment.
What are the Safe Dosages of Abel 40mg?
Recommended Dose for High Blood Pressure (Hypertension)
- Starting Dose: One tablet (40mg Azilsartan + 12.5mg Chlorthalidone) once daily
- Maintenance Dose: One tablet per day (maybe increased if necessary)
- Maximum Dose: 80mg Azilsartan + 25mg Chlorthalidone per day or as prescribed.
- Take at the same time every day for the best results.
- Swallow whole with water, with or without food.
- Avoid stopping suddenly–it may cause a spike in blood pressure.
Dose Adjustments in Special Cases
Patients with Kidney Problems
- Use it cautiously–Chlorthalidone can affect kidney function.
- Doctors may lower or adjust the dosage based on kidney function tests.
Elderly Patients
- Usually, one tablet per day is enough.
- Doctors recommend close BP monitoring to avoid excessive drops.
Patients Already on Other BP Medications
- If switching from another ARB (like Telmisartan or Losartan), start with one tablet per day.
- The doctor may adjust based on the BP response.
Warnings
- Do NOT stop suddenly–it may cause a dangerous blood pressure spike.
- Avoid alcohol & dehydration, as it may enhance the BP-lowering effect.
- Regular BP monitoring is necessary to adjust the dose if needed.
How to take Abel 40mg?
General Guidelines for Taking Abel 40mg
- Take Abel tablet once daily or as prescribed by your doctor.
- Swallow the tablet whole with a glass of water—do not crush or chew it.
- You can take it with or without meals, but taking it at the same time daily improves consistency.
- Avoid pausing the dosages, as it can cause a dangerous spike in blood pressure.
- If you feel dizzy, take it at bedtime to minimize the side effects.
Best Time to Take Abel 40mg
- Morning: Recommended for most patients to control blood pressure throughout the day.
- Night (Before Bed): If Abel 40mg makes you feel dizzy or lightheaded, take it at night instead.
Special Instructions Based on Medical Conditions
Kidney Patients
- Take it cautiously. Chlorthalidone can affect kidney function.
- Drink plenty of water to prevent dehydration.
Older Patients
- Take at the same time daily to avoid fluctuations in BP.
- Sit or stand up slowly to prevent dizziness.
Patients Already on Other BP Medications
Your doctor may adjust the dose gradually if switching from another antihypertensive drug.
Missed Dose
- Take Abel as you remember, or if it is close to the next dose, skip it—do NOT take a double dose to catch up.
Overdose Symptoms (Seek Emergency Help Immediately)
- Severe dizziness or fainting
- Extreme low blood pressure (hypotension)
- Rapid or irregular heartbeat
Warnings
- Avoid alcohol, as it can increase dizziness and lower BP too much.
- Limit salt intake, as excess sodium can reduce the effectiveness of the medication.
- Stay hydrated, as Chlorthalidone can cause increased urination.
- Regularly monitor blood pressure to track its effectiveness.
When Should I Avoid Abel 40mg or Use Abel 40mg Cautiously?
When to AVOID Abel 40mg Completely
Severe Kidney Disease or Kidney Failure
Chlorthalidone (Diuretic) can worsen kidney function by reducing fluid levels too much. Patients with severe renal impairment or dialysis-dependent kidney disease should avoid Abel 40mg.
Severe Liver Disease (Cirrhosis, Hepatic Failure)
Chlorthalidone can cause electrolyte imbalances and worsen liver disease. In patients with hepatic coma or liver failure, avoid using Abel 40mg.
Pregnancy (All Trimesters)
Azilsartan (ARB) can cause severe defects and fetal harm. Should immediately discontinue it if detected pregnant.
Allergy to Azilsartan, Chlorthalidone, or Sulfa Drugs
If you have a history of allergic reactions (rash, swelling, breathing issues) to these drugs, avoid Abel 40mg.
Severe Hypotension (Very Low Blood Pressure)
Patients with already low blood pressure should not take Abel 40mg, as it can cause fainting, shock, or organ damage.
When to Use Abel 40mg with Caution
Mild to Moderate Kidney Disease
Chlorthalidone can worsen kidney function. Regular kidney function tests (creatinine, eGFR) are required to monitor safety.
Electrolyte Imbalances (Low Potassium, Sodium, or Magnesium)
Chlorthalidone increases urine output, which can cause low potassium (hypokalemia) and low sodium (hyponatremia). Patients with electrolyte disorders should monitor their levels regularly.
Diabetes (Can Affect Blood Sugar Levels)
Chlorthalidone may increase blood sugar. Adjust diabetes medications. Doctors would recommend regular blood sugar checks.
Heart Conditions (Heart Failure, Arrhythmias)
Azilsartan lowers blood pressure, which is beneficial for heart health, but excessive lowering can cause dizziness or fainting. Chlorthalidone can cause irregular heartbeats if potassium levels drop too low.
Elderly Patients (Above 65 Years)
More prone to dizziness, dehydration, and electrolyte imbalances. You may need to adjust the dose and closely monitor BP.
Patients Taking Other Blood Pressure or Diuretic Medications
One must not combine Abel 40mg with other ARBs (like Losartan and Telmisartan) without a doctor's supervision. Avoid taking it alongside potent diuretics, as it may cause excessive dehydration and low BP.
Precautions
- Do NOT pause the doses suddenly–it may cause a dangerous rebound increase in blood pressure.
- Avoid excessive alcohol, as it may lower blood pressure too much.
- Monitor kidney function, electrolyte levels, and blood pressure regularly.
- Stay hydrated, as Chlorthalidone increases urination.
What are the Side effects of Abel 40mg?
Common Abel 40mg Side Effects
- Dizziness or Lightheadedness–because of lowered blood pressure, especially when standing up quickly.
- Increased Urination–Chlorthalidone is a diuretic, causing more frequent urination.
- Fatigue or Weakness–because of fluid and electrolyte loss.
- Muscle Cramps or Leg Pain–may result from low potassium or magnesium levels.
- Headache–Common in the first few days but usually improves.
Severe Abel 40mg Side Effects
- Severe Dizziness, Fainting, or Very Low Blood Pressure–May suggest excessive BP drop.
- Irregular or Fast Heartbeat (Arrhythmia)–because of electrolyte imbalance.
- Extreme Weakness, Confusion, or Mood Changes–Could signal low sodium or potassium.
- Severe Dehydration (Dark Urine, Dry Skin, Extreme Thirst)–because of excessive urination.
- Sudden Swelling of Face, Lips, or Throat (Allergic Reaction)–Requires emergency care.